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  • 【实验动物供应】金黄地鼠 发布时间:2023年02月27日

    联系人: 赵立斌      信息有效期:0天

    供应详细说明:

    金黄地鼠

    应用特性

    1、腮囊—其薄膜能够完全往外翻转供作实验研究

    2、血管系统研究—腮囊外翻时其血管可以肉眼清晰观察到

    3、肿瘤成长研究—地鼠的腮囊上没有淋巴液的流注,因此同质(iso-),异质(allo-)及异体肿瘤等皆可在腮囊成长。

    4、新生地鼠对于致肿瘤病毒的易感性。

    5、地鼠肾细胞可作为某些疫苗生产的原料。

     


  • 【实验动物供应】B6.CB17-Prkdcscid/SzJ 发布时间:2023年02月23日

    联系人:国家啮齿类实验动物资源库      信息有效期:0天

    供应详细说明:

    品系名称:B6.CB17-Prkdcscid/SzJ

    • 基本信息

    • 简称:B6 scid;

      编号:001913 (Jackson)

      科技资源标识:

      分类:小鼠,基因工程小鼠,自发突变

      繁殖方案:纯合子 x 纯合子(♀ × ♂)

      代次:? F6 (2015-04-23)

      来源:

      → Prkdcscid occurred spontaneously in a colony of BALB/c-Ighb (C.B-17) mice maintained at the Institute for Cancer Research in Philadelphia, PA. The mutation was transferred to the C57BL/6J background by an initial cross between C.B-17-Prkdcscid/Prkdcscid and C57BL/6J followed by sequential backcrossing of heterozygous animals of the F1 and male heterozygotes (identified by testcrossing) of subsequent generations to C57BL/6J. At the 10th backcross generation the mutation was made homozygous by brother-sister inbreeding.(来自Jackson网站)

      → 2011年7月引进种鼠,来源Jackson实验室;

      → 同胞兄妹交配6代

      引种和保存:

      2011年7月16日引入本单位

      功能及用途:

      This mouse can be used to support research in many areas including:

      Research Tools

      Immunology, Inflammation and Autoimmunity Research

      B and T cell deficiency

      Prkdcscid related

      Immunology, Inflammation and Autoimmunity Research

      Immunodeficiency

      B and T cell deficiency

      Internal/Organ Research

      Lymphoid Tissue Defects

      B and T cell deficiency

      Research Tools

      Cancer Research

      B and T cell deficiency, xenograft/transplant host

      Toxicology Research

      xenograft/transplant host

      Virology Research

      B and T Cell Deficiency

      AIDS research tool (来自Jackson网站)

      生物学特征描述:

      Mice homozygous for the severe combined immune deficiency spontaneous mutation (Prkdcscid, commonly referred to as scid) are characterized by an absence of functional T cells and B cells, lymphopenia, hypogammaglobulinemia, and a normal hematopoietic microenvironment. Normal antigen-presenting cell, myeloid, and NK cell functions are strain dependent. scid mice carry a DNA repair defect and a defect in the rearrangement of genes that code for antigen-specific receptors on lymphocytes. Most homozygotes have no detectable IgM, IgG1, IgG2a, IgG2b, IgG3, or IgA. Thymus, lymph nodes, and splenic follicles are virtually devoid of lymphocytes. scid mice accept allogeneic and xenogeneic grafts making them an ideal model for cell transfer experiments. Some scid mice will spontaneously develop partial immune reactivity. scid mice that have serum Ig levels greater than 1 ug/ml are considered "leaky." scid leakiness is highly strain dependent, increases with age, and is higher in mice housed under non-SPF conditions. In general, scid leakiness is high on the C57BL/6J and BALB/cBy genetic backgrounds, low on the C3H/HeJ background, and even lower on the NOD/ShiLtSz background.(来自Jackson网站)


  • 【实验动物供应】B6.Cg-Tg(Lck-cre)548Jxm /J 发布时间:2023年02月21日

    联系人:国家啮齿类实验动物资源库      信息有效期:0天

    供应详细说明:

    品系名称:B6.Cg-Tg(Lck-cre)548Jxm /J

    • 基本信息

    • 简称:Lck-cre;

      编号:003802 (Jackson)

      科技资源标识:

      分类:小鼠,基因工程小鼠,转基因

      繁殖方案:纯合子 x 纯合子(♀ × ♂)

      代次:? N4 6N1F6 N7 N3 (2015-04-23)

      来源:

      → A transgenic construct containing a Cre recombinase gene under the control of the Lck promoter was used to create this mutation. The construct was injected either into B6D2F1 or B6CBAF2 zygotes to obtain founder animals. (来自Jackson网站)

      → 2012年5月从南京大学引进种鼠;

      → 与本单位B6回交3代;

      引种和保存:

      2012年5月31日引入本单位

      功能及用途:

      This mouse can be used to support research in many areas including:

      Research Tools

      Cre-lox System

      Cre Recombinase Expression

      Genetics Research

      Mutagenesis and Transgenesis

      Mutagenesis and Transgenesis: Cre-lox System

      Cre related

      Research Tools

      Cre-lox System

      Genetics Research

      Mutagenesis and Transgenesis

      Mutagenesis and Transgenesis: Cre-lox System (来自Jackson网站)

      生物学特征描述:

      This transgenic strain expresses Cre under the control of the Lck (lymphocyte protein tyrosine kinase) promoter, enabling thymocyte-specific excision of loxP-flanked sequences of interest. Homozygous mice are viable and have no major defects.

      When crossed with floxed Galnt13 mice (see Stock No. 006896), excision occurs at high efficiency in thymocytes. Splenic CD4 T cells show excision at somewhat lower rates (66-83%).

      The Lck gene is primarily expressed by T lymphocytes where it phosphorylates tyrosine residues of proteins involved with intracellular signaling pathways. Associating with CD4 and CD8, LCK is part of a cascade of responses to antigen that control the proliferation and activation of T cells. It plays a key role in the selection and maturation of developing T-cells in the thymus and in the activity of mature T-cells.(来自Jackson网站)


  • 【实验动物供应】ddY 发布时间:2023年02月20日

    联系人:国家啮齿类实验动物资源库      信息有效期:0天

    供应详细说明:

    品系名称:ddY

    • 基本信息

    • 简称:ddY;

      编号:NR010200004

      科技资源标识:CSTR:15497.09.NR010200004

      分类:小鼠,封闭群

      繁殖方案:避免近亲交配;循环交配(♀ × ♂)

      代次: ? (2016-11-23)

      来源:

      → 2011年10月从日本脏器制药公司引进100对种子。

      引种和保存:

      2011年10月25日引入,由本单位保存至今。

      功能及用途:

      常用于药理、毒理研究和生物制品的检定。

      生物学特征描述:

      被毛白色,繁殖力强,产仔成活率高,雄性好斗。

    • 血液生理参数

    • 血液生理参数(4周龄)

      参数雄性雌性
      红细胞计数9.915714±1.290886×10^6/μL9.91±0.99293×10^6/μL
      红细胞体积14.04545±1.648875fL15.49524±1.717695fL
      红细胞分布宽度14.41364±1.22486%CV14.2381±0.901929%CV
      血红蛋白141.2727±15.75461g/L153.4762±19.72212g/L
      压积47.35±8.040715%44.87619±4.317396%
      血红蛋白含量14.04545±1.648875pg15.49524±1.717695pg
      血红蛋白浓度289.1818±65.93694g/L342.4762±33.51659g/L
      白细胞计数4.481818±1.614115×10^3/μL4.847619±1.403787×10^3/μL
      淋巴细胞79.47273±9.228743%75.7619±7.484215%
      血小板计数656.25±216.0611×10^3/μL546.9048±242.9479×10^3/μL
      血小板平均容积4.259091±1.320411fL5.090476±1.61056fL
      血小板分布宽度17.08182±1.259114%16.69048±0.758225%

      血液生理参数(8周龄)

      参数雄性雌性
      红细胞计数12.50714±1.462386×10^6/μL11.34227±1.28344×10^6/μL
      红细胞体积43.52381±0.872872fL43.3913±3.726309fL
      红细胞分布宽度12.17619±0.812345%CV12.21304±1.196702%CV
      血红蛋白159.7619±14.88927g/L154.8696±16.93921g/L
      压积54.80952±6.609153%50.17727±5.667445%
      血红蛋白含量12.78095±0.765911pg13.27826±2.484306pg
      血红蛋白浓度292.9048±18.76141g/L302.6522±49.5063g/L
      白细胞计数6.9±2.044994×10^3/μL6.278261±2.575577×10^3/μL
      淋巴细胞78.25238±7.331277%69.92174±16.23008%
      血小板计数837.35±166.7902×10^3/μL662.2174±316.4572×10^3/μL
      血小板平均容积3.533333±0.449815fL3.916087±1.175592fL
      血小板分布宽度16.44762±0.637667%16.22609±0.877609%
    • 血液生化参数

    • 血液生化参数(4周龄)

      参数雄性雌性
      Ca2.919±0.097mmol/L2.902±0.124mmol/L
      P
      3.827±0.442mmol/L3.27±0.413mmol/L
      门冬氨酸氨基转氨酶164.4±78U/L172.3±94.9U/L
      丙氨酸氨基转氨酶40.5±30.7U/L38.7±16.7U/L
      碱性磷酸酶291.3±42.5U/L136.±40.6U/L
      尿素氮9.777±1.243mmol/L11.363±1.678mmol/L
      总胆固醇4.3294±0.5207mmol/L3.3488±0.6373mmol/L
      血清总蛋白59.052±3.931g/L52.304±6.216g/L
      白蛋白35.758±1.602g/L32.363±2.988g/L
      甘油三脂2.4297±0.4881mmol/L
      血糖3.822±1.025mmol/L4.468±0.944mmol/L

      血液生化参数(8周龄)

      参数雄性雌性
      Ca
      2.868571±0.090238mmol/L2.868571±0.090238mmol/L
      P3.142381±0.639827mmol/L3.395417±0.6525mmol/L
      门冬氨酸氨基转氨酶145.381±48.16064U/L133.125±61.61191U/L
      丙氨酸氨基转氨酶48.57143±35.64628U/L49.29167±50.69558U/L
      碱性磷酸酶250.3333±73.84804U/L263.4167±57.12071U/L
      尿素氮8.076667±1.558613mmol/L7.701667±0.913192mmol/L
      总胆固醇3.993048±0.765568mmol/L4.471391±0.682961mmol/L
      血清总蛋白64.23857±4.560443g/L65.58667±3.707982g/L
      白蛋白38.33429±1.778656g/L38.12667±1.605955g/L
      甘油三脂3.351381±1.098398mmol/L3.059±0.617595mmol/L
      血糖5.642857±1.742543mmol/L6.481667±1.372866mmol/L


    • 【实验动物供应】Nifdc:Wistar 发布时间:2023年02月14日

      联系人:国家啮齿类实验动物资源库      信息有效期:0天

      供应详细说明:

      品系名称:Nifdc:Wistar

      • 基本信息

      • 简称:Wistar;

        编号:NR020200001

        科技资源标识:CSTR:15497.09.NR020200001

        分类:大鼠,封闭群

        繁殖方案:避免近亲交配;循环交配(♀ × ♂)

        代次:

        来源:

        → 不详

        引种和保存:

        引入本单位时间不详

        功能及用途:

        Wistar大鼠对各种营养物质敏感,适用于各种营养、代谢性疾病 研究。垂体肾上腺系统发达,应激反应灵敏,适用于神经-内分泌实验研究。还用于药物、肿瘤、传染病、关节炎、肝外可等医学研究领域。是生物医学研究中使用历史最长的大鼠品系。

        生物学特征描述:

        1907年由美国维斯塔尔(Wistar)研究所育成,现己遍及世界各国的实验室。我国从日本及前苏联引进,是引进最早、使用最广泛、数量最多的大鼠品系之一。主要特性包括:头部较宽、耳朵较长、尾的长度小于身长;性周朝稳定,繁殖力强,产仔多,平均每胎产仔在10只左右,生长发育快。10周龄时雄鼠体重可达280~300g,雌鼠达170-260g;性情温顺;对传染病的抵抗力较强;自发性肿瘤发生率低;目前各地饲养的Wisstar大鼠的遗传状况差异较大。Wistar大鼠既有近交系,又有远交群。

      • 血液生理参数

      • 血液生理参数(8周龄)

        参数雄性雌性
        红细胞计数7.22±0.670×10^6/μL6.95±0.428×10^6/μL
        红细胞体积57.63±1.165fL56.65±1.182fL
        红细胞分布宽度11.71±0.288%CV11.03±0.331%CV
        血红蛋白139.95±10.036g/L130.10±40.164g/L
        压积41.74±4.083%39.26±1.991%
        血红蛋白含量19.89±2.485pg22.27±7.613pg
        血红蛋白浓度336.42±17.893g/L379.60±67.794g/L
        白细胞计数15.17±3.457×10^3/μL11.68±2.766×10^3/μL
        淋巴细胞62.62±6.108%70.17±4.889%
        血小板计数429.05±79.327×10^3/μL286.10±103.856×10^3/μL
        血小板平均容积5.49±0.553fL6.67±1.337fL
        血小板分布宽度16.37±0.760%16.82±0.732%
      • 血液生化参数

      • 血液生化参数(8周龄)

        参数雄性雌性
        Ca1.474737±0.239058mmol/L

        2.276±0.66224mmol/L

        血液pH7.14-7.377.14-7.37
        门冬氨酸氨基转氨酶41.52632±8.526875U/L83.5±30.94222U/L
        丙氨酸氨基转氨酶17.15789±5.13445U/L28.9±10.95877U/L
        碱性磷酸酶108.2632±27.65028U/L135.8±72.12533U/L
        乳酸脱氢酶104.6316±68.12669U/L321.45±209.8693U/L
        尿素氮3.607368±0.597726mmol/L3.9425±1.17285mmol/L
        血清总蛋白25.10526±4.875047g/L41.05±12.70505g/L
        白蛋白17.31579±2.789915g/L25.7±6.190825g/L
        甘油三脂0.698421±0.18718mmol/L1.3905±0.351949mmol/L
        血糖3.134211±0.509633mmol/L5.169±1.099411mmol/L


      • 【实验动物供应】C57BL/6J-Tg(Alb1HBV)44Bri/J 发布时间:2023年02月07日

        联系人:国家啮齿类实验动物资源库      信息有效期:0天

        供应详细说明:

        品系名称:C57BL/6J-Tg(Alb1HBV)44Bri/J

        • 基本信息

        • 简称:HBs-tg;50-4

          编号:002226 (Jackson)

          科技资源标识:

          分类:小鼠,基因工程小鼠,转基因

          繁殖方案:野生型 x 半合子(♀ × ♂)

          代次:? F7(2014-12-11)

          来源:

          → This strain is referred to as "50-4" or "Tg(Alb1-HBV)Bri44" in the primary reference.(来自Jackson网站)

          → 2011年12月从南京大学引进种鼠;

          → 同胞兄妹交配7代

          引种和保存:

          2011年12月12日引入本单位

          功能及用途:

          This mouse can be used to support research in many areas including:

          Apoptosis Research

          Death Receptors

          Cancer Research

          Genes Regulating Growth and Proliferation

          Growth Factors/Receptors/Cytokines

          Increased Tumor Incidence

          Hepatomas

          Hepatomas: hepatacellular carcinoma

          Virology Research

          Hepatitis B Virus (来自Jackson网站)

          生物学特征描述:

          This strain is referred to as "50-4" or "Tg(Alb1-HBV)Bri44" in the primary reference. These mice may be useful for studying hepatocellular carcinoma.(来自Jackson网站)


      • 【实验动物供应】B6;129S6-Chattm2(cre)Lowl/J 发布时间:2023年02月07日

        联系人:国家啮齿类实验动物资源库      信息有效期:0天

        供应详细说明:

        品系名称:B6;129S6-Chattm2(cre)Lowl/J

        • 基本信息

        • 简称:ChAT-IRES-Cre;

          编号:006410 (Jackson)

          科技资源标识:

          分类:小鼠,基因工程小鼠

          繁殖方案:Homozygote x Homozygote(♀ × ♂)

          代次:N? F11 F4 (2015-04-27)

          来源:

          → A targeting vector was designed to insert an optimized internal ribosome entry site-linked Cre recombinase gene (followed by an frt-flanked neomycin resistance cassette) downstream of the stop codon of the endogenous gene. The construct was electroporated into 129S6/SvEvTac-derived W4 embryonic stem (ES) cells. Correctly targeted ES cells were injected into C57BL/6 blastocysts. Chimeric mice were bred to C57BL/6 mice. The resulting mutant offspring (still retaining the frt-flanked neo) were bred to wildtype siblings, and maintained as such prior to sending heterozygous males to The Jackson Laboratory Repository in 2006. Upon arrival, mice were bred once to C57BL/6 females to rederive our living colony. Thereafter, mutant mice were bred together to make this line homozygous.(来自Jackson网站)

          → 2012年11月自南京大学引进种鼠;

          → 同胞兄妹交配4代

          引种和保存:

          2011年11月引入本单位

          功能及用途:

          This mouse can be used to support research in many areas including:

          Neurobiology Research

          Alzheimer's Disease

          Cre-lox System

          Cre Recombinase expression in neural tissue

          Down syndrome

          Neurodegeneration

          basal forebrain cholinergic neurons, Down syndrome

          Research Tools

          Cancer Research

          Cre-lox System

          Cardiovascular Research

          Cre-lox System

          Cre-lox System

          Cre Recombinase Expression

          Developmental Biology Research

          Cre-lox System

          Diabetes and Obesity Research

          loxP

          Genetics Research

          Mutagenesis and Transgenesis

          Mutagenesis and Transgenesis: Cre-lox System

          Tissue/Cell Markers

          Tissue/Cell Markers: Cre-lox System

          Neurobiology Research

          Cre related

          Research Tools

          Cre-lox System

          Genetics Research

          Mutagenesis and Transgenesis

          Mutagenesis and Transgenesis: Cre-lox System (来自Jackson网站)

          生物学特征描述:

          Mice that are homozygous for the ChAT-IRES-Cre knockin are viable and fertile. An "IRES-Cre" sequence is inserted downstream of the stop codon such that cre expression is controlled by the endogenous Chat gene promoter. Chat gene expression, however, is unaffected. Cre recombinase activity is reported in all cholinergic neurons. These mice may be useful for "Cre-lox" technology applications in neurobiology, including studies of motor function, learning and memory, Alzheimer's disease, and Down syndrome, and in obesity and diabetes research.(来自Jackson网站)


      • 【实验动物供应】FVB-Tg(Ddx4-cre)1Dcas/J 发布时间:2023年02月03日

        联系人:国家啮齿类实验动物资源库      信息有效期:0天

        供应详细说明:

        品系名称:FVB-Tg(Ddx4-cre)1Dcas/J

        • 基本信息

        • 简称:Vasa-Cre; Ddx4-cre;

          编号:006954 (Jackson)

          科技资源标识:

          分类:小鼠,基因工程小鼠

          繁殖方案:Noncarrier x Hemizygote(♀ × ♂)

          代次:? N9 N1F5(2015-03-23)

          来源:

          → The Vasa-Cre transgene contains a 5.6 kb fragment of the mouse Vasa (Ddx4) promoter, beta-globin intron, Cre recombinase open reading frame with nuclear localization signal, and SV40 polyadenylation signal. The transgene was microinjected into FVB oocytes. Transgenic mice (founder line not provided) on the FVB genetic background were bred together for many generations prior to arrival at The Jackson Laboratory.(来自Jackson网站)

          → 2012年6月从南京大学引进3只雄鼠,在南京大学回交9代(N9);

          → 与B6(自有)回交一代,同胞兄妹交配5代;

          引种和保存:

          2012年6月引入本单位

          功能及用途:

          This mouse can be used to support research in many areas including:

          Research Tools

          Cre-lox System

          Cre Recombinase Expression

          Cre Recombinase Expression: Germline/Embryonic Expression

          Developmental Biology Research

          Cre-lox System

          Genetics Research

          Mutagenesis and Transgenesis

          Mutagenesis and Transgenesis: Cre-lox System

          Tissue/Cell Markers

          Tissue/Cell Markers: Cre-lox System

          Tissue/Cell Markers: primordial germ cell marker

          Reproductive Biology Research

          Cre-lox System

          male germ cells

          oocyte

          primordial germ cell marker

          cre related

          Research Tools

          Cre-lox System

          Genetics Research

          Mutagenesis and Transgenesis

          Mutagenesis and Transgenesis: Cre-lox System (来自Jackson网站)

          生物学特征描述:

          Mice hemizygous for this Ddx4 (or Vasa)-Cre transgene are viable and fertile. Transgenic cre activity is directed to male and female germ cells starting at embryonic day (e)15-e18. When bred with mice containing a loxP-flanked sequence of interest, Cre-mediated recombination will result in deletion of the flanked sequence. In such breedings, occasional hemizygous mice may exhibit variegated cre expression in skin epithelium or global cre expression (<20% incidence). Differential parent-of-origin transgene expression is observed. When the mother harbors Ddx4-Cre, virtually all progeny undergo global Cre-mediated recombination, even those that do not inherit the transgene (which may be useful in converting a "floxed" allele to a null while obviating the need to perform additional crosses to remove the transgene). To achieve germ-line specific Cre-mediated recombination in offspring, paternal Ddx4-Cre mice should be used.

          In crosses with some floxed alleles, global recombination may occur even when males are used as the Dxd4-Cre carriers. The basis of this "paternal" effect is not known, but may relate to the presence of Cre protein in sperm. This global recombination can occur more frequently with older males. Thus, when paternal-effect global recombination is observed, it is recommended that the youngest available Ddx4-Cre males be used for breeding (ideally 5-6 weeks, but less than 9 weeks of age). Once a male has proven to repeatedly give rise to globally-recombined progeny, he should no longer be used as a breeder.

          These Ddx4-Cre mice may be useful in generating conditional germ cell knockouts in both males and females for studies including infertility, gonadogenesis, gametogenesis, and the assembly, activation, and growth of primordial follicles.

          While another germ line cre-expressing strain, ZP3-Cre (see Stock No. 003651), permits recombination/deletion of loxP-flanked genes in growing follicles, Ddx4-Cre mice have additional cre expression in primordial follicles (early oogenesis) and in the male germline. (来自Jackson网站)


      • 【实验动物供应】B6.Cg-Tg(Alb-cre)21Mgn/J 发布时间:2023年01月31日

        联系人:国家啮齿类实验动物资源库      信息有效期:0天

        供应详细说明:

        品系名称:B6.Cg-Tg(Alb-cre)21Mgn/J

        • 基本信息

        • 简称:Alb-Cre;

          编号:003574 (Jackson)

          科技资源标识:

          分类:小鼠,基因工程小鼠,转基因

          繁殖方案:Homozygote x Homozygote(♀ × ♂)

          代次:? F6(2015-03-25)

          来源:

          → A transgenic construct containing a 2.34 kbp mouse albumin enhancer/promoter, nuclear localization sequence-modified Cre recombinase and a 2.1 kbp fragment from the human growth hormone gene was injected into B6D2(F2) pronuclei. These mice were subsequently backcrossed to C57BL/6J mice.(来自Jackson网站)

          → 种鼠来自南京大学——南京生物医药研究院;

          → 同胞兄妹交配6代;

          引种和保存:

          2012年10月引入本单位

          功能及用途:

          This mouse can be used to support research in many areas including:

          Research Tools

          Cre-lox System

          Cre Recombinase Expression

          Genetics Research

          Mutagenesis and Transgenesis

          Mutagenesis and Transgenesis: Cre-lox System

          Tissue/Cell Markers

          Cre related

          Research Tools

          Cre-lox System

          Genetics Research

          Mutagenesis and Transgenesis

          Mutagenesis and Transgenesis: Cre-lox System (来自Jackson网站)

          生物学特征描述:

          This strain may be maintained as a hemizygote or homozygote and lacks any phenotype related to the transgenic allele. It has been well characterized and shown to be very efficient for performing liver-specific gene knockouts using Cre/loxP system. This line has been shown to be nearly 100% efficient in achieving liver-specific recombination when crossed with at least five different floxed alleles.(来自Jackson网站)


      • 【实验动物供应】C3H/HeJNifdc 发布时间:2023年01月29日

        联系人:国家啮齿类实验动物资源库      信息有效期:0天

        供应详细说明:

        品系名称:C3H/HeJNifdc

        • 基本信息

        • 简称:C3H;C3

          编号:NR00209

          科技资源标识:CSTR:15497.09.NR00209

          分类:小鼠,近交系

          繁殖方案:兄妹交配

          代次:? F19(2004年在我单位进行剖腹产进化)

          来源:

          → 1920年Strong将一只Bagg albino雌鼠和一只DBA雄鼠进行杂交得到该品系,1930年Andervont引入了该品系的4只雌性和2只雄性鼠,随后Heston引入了第35代,1951年NIH从Heston引入第57代,1974年Charles River从NIH引入并于1975年进行了剖腹产,2001年维通利华从Charles River引入该品系1974年Charles River从NIH引入并于1975年进行剖腹产
          → 2001年维通利华从Charles River引入该品系。

          引种和保存:

          2001年从维通利华引入本单位

          功能及用途:

          主要用于肿瘤学、生理学、免疫学等研究。

          生物学特征描述:

          棕灰色(野生型),对致肝癌因子敏感,10月龄乳腺癌发病率97%,14月龄雄性小鼠肝癌发病率85%,对狂犬病毒敏感,对炭疽杆菌有抗力,补体活性高,较易诱发免疫耐受,红细胞及白细胞数较少。

        • 血液生理参数

        • 血液生理参数(4周龄)

          参数雄性雌性
          红细胞计数8.68±0.61×10^6/μL9.23±0.62×10^6/μL
          红细胞体积62.94±1.10fL61.54±1.13fL
          红细胞分布宽度13.67±0.24%CV13.66±0.31%CV
          血红蛋白137.00±9.60g/L145.00±10.37g/L
          压积54.64±3.79%56.78±3.77%
          血红蛋白含量15.79±0.30pg15.70±0.26pg
          血红蛋白浓度250.60±4.17g/L255.40±5.19g/L
          白细胞计数4.30±0.79×10^3/μL5.76±1.48×10^3/μL
          淋巴细胞96.36±1.73%97.92±2.29%
          血小板计数650.50±72.78×10^3/μL661.30±71.16×10^3/μL
          血小板平均容积2.31±0.20fL2.41±0.25fL
          血小板分布宽度21.60±0.69%20.78±1.15%

          血液生理参数(8周龄)

          参数雄性雌性
          红细胞计数8.58±1.57×10^6/μL9.07±0.64×10^6/μL
          红细胞体积60.66±2.86fL58.95±1.78fL
          红细胞分布宽度13.77±1.44%CV13.25±0.21%CV
          血红蛋白132.63±20.29g/L141.20±11.26g/L
          压积51.71±8.29%53.45±3.99%
          血红蛋白含量15.59±0.84pg15.56±0.31pg
          血红蛋白浓度256.90±7.02g/L264.16±8.51g/L
          白细胞计数7.74±1.40×10^3/μL5.69±0.92×10^3/μL
          淋巴细胞99.44±0.70%99.39±0.82%
          血小板计数684.13±124.86×10^3/μL579.24±100.98×10^3/μL
          血小板平均容积2.38±0.48fL2.60±0.47fL
          血小板分布宽度20.46±0.99%20.86±0.88%
        • 血液生化参数

        • 血液生化参数(4周龄)

          参数雄性雌性
          Ca
          2.58±0.05mmol/L2.66±0.12mmol/L
          P3.49±0.38mmol/L3.58±0.31mmol/L
          门冬氨酸氨基转氨酶100.24±15.71U/L154.58±114.74U/L
          丙氨酸氨基转氨酶21.48±5.02U/L38.92±26.29U/L
          碱性磷酸酶238.75±11.76U/L287.84±12.44U/L
          肌苷48.40±1.00mmol/L57.23±13.22mmol/L
          尿素氮8.66±0.81mmol/L10.41±1.31mmol/L
          总胆固醇4.15±0.14mmol/L3.31±0.17mmol/L
          血清总蛋白55.88±1.36g/L57.21±3.82g/L
          白蛋白35.60±1.80g/L36.63±3.19g/L
          甘油三脂1.73±0.43mmol/L1.56±0.25mmol/L
          血糖4.48±0.41mmol/L2.64±0.61mmol/L

          血液生化参数(8周龄)

          参数雄性雌性
          Ca
          2.28±0.44mmol/L2.39±0.08mmol/L
          P2.86±0.69mmol/L3.17±0.21mmol/L
          门冬氨酸氨基转氨酶220.79±184.13U/L243.76±124.25U/L
          丙氨酸氨基转氨酶44.43±33.09U/L41.60±27.75U/L
          碱性磷酸酶171.72±47.79U/L237.04±19.24U/L
          肌苷59.10±18.80mmol/L91.43±36.93mmol/L
          尿素氮10.53±5.11mmol/L9.27±1.25mmol/L
          总胆固醇3.56±0.78mmol/L3.23±0.24mmol/L
          血清总蛋白61.09±12.45g/L63.00±2.57g/L
          白蛋白39.63±7.95g/L42.35±1.56g/L
          甘油三脂2.97±1.01mmol/L2.53±0.77mmol/L
          血糖3.73±0.98mmol/L3.32±0.67mmol/L