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品系名称：
人DPP4超表达小鼠
基本信息
简称：
编号：
科技资源标识：CSTR:15497.09.HBYKD010400001
分类：小鼠,基因工程小鼠
繁殖方案：SPF级常规饲养
代次：F3
来源：
引种和保存：
功能及用途：
血糖调控及冠状病毒研究
生物学特征描述：
品系名称：Gal抗原缺失模式兔
基本信息
简称：
编号：NR040400001
科技资源标识：CSTR:15497.09.NR040400001
分类：兔,基因工程小鼠,靶突变KO
繁殖方案：
代次：
来源：
中国食品药品检定研究院的研究团队选用SPF级6-8月龄新西兰白兔，采用CRISPR/Cas9介导的基因编辑技术，针对调控兔子Gal抗原表达的GGTA1基因第8外显子设计构建2条相辅的sgRNA。经转录后将GGTA1 sgRNA mRNAs与Cas9 mRNA共显微注射到体外培养的兔子受精卵中，继续短暂体外培养后植入代孕母兔体内，经自然妊娠获得仔兔。
引种和保存：
功能及用途：
可应用于动物源性医疗器械的免疫原性风险评价和异种骨、角膜等原位植入实验等。
生物学特征描述：
Gal抗原缺失模式兔与新西兰白兔在体质量方面无显著性差异。
F0代的Gal抗原缺失模式兔的主要脏器（心、肝、脾、肺、肾）中Gal抗原的表达水平比新西兰白兔均降低了99.96%以上。
在新西兰白兔中不产生针对Gal抗原的IgG和IgM抗体，而在F1代的Gal抗原缺失模式兔中特异性抗Gal的IgG和IgM抗体水平随着年龄的增长而增加，在大约5~6个
品系名称：
BN/SsNSlcNifdc
基本信息
简称：BN
编号：NR020100001
科技资源标识：CSTR:15497.09.NR020100001
分类：大鼠,近交系
繁殖方案：同胞兄妹交配（♀ × ♂）
代次：
来源：
Wistar研究所的King（Helen Dean King）从野外捕获的野生Norway大鼠进行圈养繁殖，1930年发现一个深色（巧克力色）突变的大鼠，Aptekman（Paul Aptekman）对该大鼠一直维持着小规模繁殖维持，直到1958年，WK Silvers和RE Billingham对这个品系大鼠进行皮肤移植的组织相容性研究，发现该大鼠与随机挑选的大鼠进行皮肤交叉移植后30%的宿主中移植皮肤至少能够存活100天。于是，针对突变和彼此的皮肤兼容性进行近交筛选，在近交筛选3代内获得了组织相容性基因完全一致的品系，表现为在相同性别之间和从雌性移植到雄性，都在100天内移植皮肤无排异，说明Y染色体有关的组织相容性抗原一致性在其中发挥作用。
该杂交品系大鼠在1976年从荷兰的放射生物学研究所引进到 Charles River公司。到达Taconi公司是第90代（F90)。我国最初于2008年自英国BKU引进。
引种和保存：
功能及用途：
(1) 生理学研究
(2) 免疫学研究和免疫抑制药物功效测试。BN大鼠对几种化学诱导疾病比较敏感，例如，多发性关节炎和辅助T细胞自身免疫（使用氯化汞或环孢菌素A）。
(3) 器官移植
在不同品系之间进行器官移植后免疫排斥反应的强度不同。例如，在Wistar大鼠和SD大鼠之间进行肝脏移植时可能出现较大的组内排斥差异。因此，Wistar和SD都不太理想。而BN大鼠组织相容性相对较高，适合进行器官移植试验。目前国际上大鼠肝移植急性排斥反应模型常选用的品系组合包括Dark Agouti (DA)大鼠→BN大鼠，DA大鼠→Lewis大鼠，DA大鼠→AUG大鼠，Lewis大鼠→BN大鼠，Lewis大鼠→AUG大鼠，等。
(4) 肿瘤移植。
(5) 呼吸系统炎症、哮喘或过敏。
肺的病理生理和免疫在各种大鼠中具有独到之处，呼吸系统炎症与过敏模型高度一致。
(6) 男性老年性生殖功能下降模型。
(7) 肿瘤诱导模型。
(8)视网膜退行性病变。
(9) 老年研究。
生物学特征描述：
(1) 自发性肿瘤发生率
雄性：自发性膀胱癌28-35 %，输尿管肿瘤6-9 %，胰岛腺瘤15%，垂体腺瘤14%，淋巴网状细胞瘤14%，甲状腺髓质瘤9%，肾上腺嗜铬细胞瘤8%，。
雌性：自发性膀胱癌2-3 %，输尿管肿瘤20-22 %，垂体腺瘤26%， 肾上腺皮质瘤19%, 阴道肉瘤（vaginal sarcoma）19 %，乳腺纤维瘤11%。随着年龄增大，肿瘤发生率升高。
口腔鳞状上皮细胞癌（oral squamous cell carcinoma）发生率：雄性约21%，雌性约32%。当采取摄食量限制（热量摄入限制）时，发生率都大幅度下降。
(2) 肿瘤移植
(3) 雄性老年生殖机能下降
表现为血浆睾酮浓度低，Leydig细胞类固醇合成能力低，Sertoli细胞数量和功能下降，输精管变小，精子减少。这些改变是由于睾丸缺陷和继发性下丘脑机能障碍两方面综合的结果。
(4) 其他
该品系存活到25月龄以上达90%，达到32~35月龄达50%。
品系名称：
BALB/cAnSlacNifdc-nu
基本信息
简称：BALB/c-nu
编号：
科技资源标识：
分类：小鼠,近交系
繁殖方案：
代次：
来源：
1973年，丹麦的C. W. Friis在BALB/c近交系小鼠中发现自发性突变的无毛小鼠，该突变小鼠胸腺发育不良，免疫T细胞缺失，而育成了BALB/c-nu小鼠。
1980年，从日本引入。
引种和保存：
功能及用途：
同种和异种移植模型，可用于评估肿瘤细胞增殖，侵袭和转移的潜力，以及抗癌疗法的功效。
免疫和遗传研究。
病毒、细菌、寄生虫感染机制的研究。
皮肤病、微生物学上的研究。
内分泌和老年医学上的应用。
生物学特征描述：
Foxn1基因的突变导致小鼠毛发生长不正常，且胸腺上皮发育不全，缺乏成熟T淋巴细胞。
血液生理参数
血液生理参数（4周龄）
| 参数 | 雄性 | 雌性 |
| 红细胞计数 | 8.04±0.673×10^6/μL | 8.41±0.986×10^6/μL |
| 红细胞体积 | 57.97±2.535fL | 57.45±2.575fL |
| 红细胞分布宽度 | 17.82±1.508%CV | 17.80±1.509%CV |
| 血红蛋白 | 113.90±8.807g/L | 119.25±13.645g/L |
| 压积 | 46.51±3.561% | 48.27±5.733% |
| 血红蛋白含量 | 14.18±0.374pg | 14.20±0.573pg |
| 血红蛋白浓度 | 244.95±7.756g/L | 247.20g/L |
| 白细胞计数 | 3.91±2.603×10^3/μL | 3.73±1.620×10^3/μL |
| 嗜中性白细胞 | 73.97±10.591% | 72.94±8.980% |
| 嗜酸性白细胞 | 0.76±0.778% | 2.03±2.506% |
| 嗜碱性白细胞 | 0.44±0.328% | 0.46±0.370% |
| 淋巴细胞 | 14.60±7.139% | 18.41±7.016% |
| 单核细胞 | 10.24±7.993% | 6.17±2.207% |
| 血小板计数 | 600.70±151.516×10^3/μL | 527.20±214.270×10^3/μL |
| 血小板平均容积 | 2.26±0.598fL | 2.82±1.058fL |
| 血小板分布宽度 | 18.82±1.412% | 18.48±1.453% |
血液生理参数（8周龄）
| 参数 | 雄性 | 雌性 |
| 红细胞计数 | 9.66±0.850×10^6/μL | 9.73±1.206×10^6/μL |
| 红细胞体积 | 55.41±1.801fL | 57.73±2.054fL |
| 红细胞分布宽度 | 13.71±0.487%CV | 13.24±0.317%CV |
| 血红蛋白 | 132.65±10.358g/L | 129.11±6.145g/L |
| 压积 | 53.47±5.007% | 56.18±7.318% |
| 血红蛋白含量 | 13.78±0.849pg | 13.42±1.419pg |
| 血红蛋白浓度 | 249.00±16.377g/L | 232.74±25.875g/L |
| 白细胞计数 | 3.57±1.092×10^3/μL | 4.89±1.952×10^3/μL |
| 嗜中性白细胞 | 71.42±9.795% | 65.32±9.892% |
| 嗜酸性白细胞 | 0.81±1.161% | 0.60±0.601% |
| 嗜碱性白细胞 | 0.62±0.416% | 0.37±0.251% |
| 淋巴细胞 | 21.02±6.167% | 29.63±8.652% |
| 单核细胞 | 6.14±5.808% | 4.07±2.808% |
| 血小板计数 | 654.15×10^3/μL | 734.74±257.846×10^3/μL |
| 血小板平均容积 | 2.25±0.506fL | 2.71±1.237fL |
| 血小板分布宽度 | 19.18±0.944% | 19.68±0.944% |
血液生化参数
血液生化参数（4周龄）
| 参数 | 雄性 | 雌性 |
| Ca | 2.58±0.066mmol/L | 2.56±0.139mmol/L |
| P | 3.46±0.293mmol/L | 3.6±0.39mmol/L |
| 门冬氨酸氨基转氨酶 | 151.9±24.05U/L | 204.5±66.75U/L |
| 丙氨酸氨基转氨酶 | 45.8±45.73U/L | 46.4±31.45U/L |
| 碱性磷酸酶 | 182.0±46.99U/L | 179.5±40.34U/L |
| 肌苷 | 68.38±25.520mmol/L | 87.97±10.757mmol/L |
| 尿素氮 | 9.98±2.125mmol/L | 9.46±1.467mmol/L |
| 总胆固醇 | 2.92±0.380mmol/L | 2.49±0.305mmol/L |
| 血清总蛋白 | 51.49±2.380g/L | 52.15±2.441g/L |
| 白蛋白 | 30.73±1.692g/L | 31.49±1.655g/L |
| 甘油三脂 | 2.73±1.017mmol/L | 3.63±1.294mmol/L |
| 血糖 | 1.17±0.486mmol/L | 1.02±0.596mmol/L |
血液生化参数（8周龄）
| 参数 | 雄性 | 雌性 |
| Ca | 2.409±0.0865mmol/L | 2.601±0.0873mmol/L |
| P | 2.847±0.2826mmol/L | 2.749±0.4257mmol/L |
| 门冬氨酸氨基转氨酶 | 145.3±25.45U/L | 177.8±119.48U/L |
| 丙氨酸氨基转氨酶 | 38.1±25.33U/L | 36.9±45.3U/L |
| 碱性磷酸酶 | 108.2±26.99U/L | 78±19.6U/L |
| 肌苷 | 72.69±24.778mmol/L | 77.49±15.821mmol/L |
| 尿素氮 | 8.262±1.5949mmol/L | 7.239±1.0904mmol/L |
| 总胆固醇 | 2.958±0.3779mmol/L | 2.333±0.2674mmol/L |
| 血清总蛋白 | 58.94±4.008g/L | 60.79±3.462g/L |
| 白蛋白 | 31.83±1.291g/L | 33.81±0.948g/L |
| 甘油三脂 | 2.497±0.6603mmol/L | 1.766±0.7143mmol/L |
| 血糖 | 2.69±0.8755mmol/L | 2.739±0.9098mmol/L |
品系名称：C57BL/6-Tg(Prnp-TARDBP*M337V)4Ptrc/J
基本信息
简称：hTDP-43M337V
编号：017604 (Jackson)
科技资源标识：
分类：小鼠,基因工程小鼠,转基因
繁殖方案：Noncarrier x Hemizygote（♀ × ♂）
代次：？ F5N1F3 （2015-03-25）
来源：
→ The hTDP-43M337V transgene was designed with the mouse prion protein (Prnp) promoter driving expression of a mutant form of the humanTARDBP gene modified to have the methionine to valine substitution at codon 337 (M337V). The transgene was microinjected into fertilized C57BL/6 oocytes. Mice from the founder line 4 were bred to C57BL/6 mice to generate the hTDP-43M337V line 4 colony. Transgenic mice from line 4 were bred together, and then maintained by breeding homozygous mice together for several generations prior to sending to The Jackson Laboratory Repository. Upon arrival, transgenic mice were bred to C57BL/6J mice (Stock No. 000664) for at least one generation to establish the colony.（来自Jackson网站）
→ 种鼠由维通利华从Jackson实验室引进；
→ 同胞兄妹交配5代，与B6回交一代，同胞兄妹繁殖3代；
引种和保存：
2011年8月引入本单位
功能及用途：
This mouse can be used to support research in many areas including:
Neurobiology Research
Amyotrophic Lateral Sclerosis (ALS)
Ataxia (Movement) Defects
Myelination Defects
Neurodegeneration
Research Tools
Neurobiology Research （来自Jackson网站）
生物学特征描述：
These hTDP-43M337V transgenic mice express a full length mutant human TAR DNA binding protein (TARDBP or TDP-43) cDNA under the direction of a mouse prion protein promoter. The cDNA is modified such that at codon 337, a methionine to replaced by a valine(43M337V). The 43M337V mutation is associated with increased low molecular weight fragments, neuronal apoptosis and developmental delay in chick embryos. TDP-43 is a ubiquinated protein localized to the nucleus of cells. Accumulations of TDP-43 are associated with the development of Amyotrophic lateral sclerosis (ALS). Hemizygotes are viable, fertile, and normal in size, while homozygotes are initially viable with 70% dying within the first month of life. These mice express human TDP-43M337V primarily in the nuclei of neurons throughout much of the gray matter of the spinal cord and brain, including the brainstem and cortex. Homozygotes and hemizygous express TDP-43M337V in brain at 2.7 and 1.9-fold endogenous TDP-43 levels, respectively. Endogenous TDP-43 is down-regulated in response to transgene overexpression. By 21 days of age homozygotes develop body tremors, have difficulty walking, and develop an irregular "dragging" gait. By 1 month of age, homozygous TDP-43M337V mutants are smaller than hemizygous littermates, exhibit muscle weakness and become unable to right themselves. These mice exhibit reactive gliosis, and TDP-43M337V /ubiquitin aggregates containing phosphorylated TDP-43M337V. Hemizygous mice are indistinguishable from wildtype littermates. These transgenic mice may be useful in studying neuromuscular and neurodegenerative disorders such as ALS (Lou Gehrig's Disease) and frontotemporal lobar degeneration with ubiquitin aggregates.（来自Jackson网站）
品系名称：NOD/ShiLt-Tg(Foxp3-EGFP/cre)1cJbs/J
基本信息
简称：NOD.Foxp3-cre;
编号：008694 (Jackson)
科技资源标识：
分类：小鼠,基因工程小鼠,转基因
繁殖方案：Noncarrier x Hemizygote（♀ × ♂）
代次： N1F8 F5 （2015-4-20）
来源：
→ The 188 kb C57BL/6J mouse bacterial artificial chromosome (BAC) RP23-143D8, containing the intact Foxp3 gene was modified by inserting an enhanced green fluorescent protein (EGFP) fused to a codon optimized "humanized" cre recombinase. This BAC transgene was injected into NOD/ShiLtJ fertilized oocytes and maintained on the same background. In 2008, the T1DR received this NOD coisogenic strain.（来自Jackson网站）
→ 2013年1月从南京大学引进种鼠；
→ 同胞兄妹交配5代
引种和保存：
2012年1月19日引入本单位
功能及用途：
This mouse can be used to support research in many areas including:
Diabetes and Obesity Research
Type 1 Diabetes (IDDM) Analysis Strains
NOD Transgenics
Research Tools
Cre-lox System
Cre Recombinase Expression
Fluorescent Proteins
Immunology, Inflammation and Autoimmunity Research
T cell specific surface marker
GFP related
Research Tools
Fluorescent Proteins
Cre related
Cre-lox System
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System（来自Jackson网站）
生物学特征描述：
Mice hemizygous for the Foxp3-EGFP/cre BAC transgene are viable and fertile. They express an enhanced green fluorescent protein and codon optimized "humanized" cre under the control of the mouse Foxp3 promoter. Transgene expression is specific to Cd4 Cd25 highCd127 low T cells from the lymph nodes, spleen and thymus. GFP expression is restricted to FoxP3 cells. This mutant mouse strain may be useful for fluorescently labeling Foxp3 T-cells to study regulatory T-cell function in autoimmunity specifically, type 1 diabetes. （来自Jackson网站）
品系名称：B6.Cg-Tg(Itgax-cre)1-1Reiz/J
基本信息
简称：Cd11c-Cre;
编号：008068 (Jackson)
科技资源标识：
分类：小鼠,基因工程小鼠,转基因
繁殖方案：sibling x Hemizygote（♀ × ♂）
代次：N12 N3F14 F3 (2015-11-25)
来源：
→ The Itgax-cre (Cd11c-Cre) BAC transgene was designed in the laboratory of Dr. Boris Reizis (Columbia University Medical Center). The mouse bacterial artificial chromosome (BAC) RP24-361C4, containing the integrin alpha X gene (Itgax or Cd11c) but lacking the 5prime end of the adjacentItgam gene, was obtained. A Cre recombinase and a polyA signal sequence was introduced into the first exon of Itgax on the RP24-361C4 BAC via homologous recombination/BAC recombineering. The resulting ~160 kbp transgenic construct was introduced into B6CBAF1/J donor eggs. Founder line 1-1 was consequently established. The mice were crossed to 129S6/SvEvTac for several generations and then backcrossed to C57BL/6 for more than 12 generations prior to sending to The Jackson Laboratory Repository in 2007. Upon arrival, the mice were crossed to C57BL/6J at least once to establish the living colony. （来自Jackson网站）
→ 2013年6月从南京大学引进种鼠；
→ 同胞兄妹交配3代
引种和保存：
2013年6月18日引入本单位
功能及用途：
Research Applications
This mouse can be used to support research in many areas including:
Developmental Biology Research
Internal/Organ Defects
hematopoietic defects
Lymphoid Tissue Defects
hematopoietic defects
Hematological Research
Hematopoietic Defects
Immunology, Inflammation and Autoimmunity Research
Lymphoid Tissue Defects
hematopoietic development
Research Tools
Cre-lox System
Cre Recombinase Expression
Genetics Research
Mutagenesis and Transgenesis: Cre-lox System
Tissue/Cell Markers: Cre-lox System
Immunology, Inflammation and Autoimmunity Research
Research Tools
Cre-lox System
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System（来自Jackson网站）
生物学特征描述：
Mice hemizygous for the Itgax-cre (Cd11c-Cre) transgene are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. These Cd11c-Cre transgenic mice express Cre recombinase under the control of the mouse integrin alpha X (Cd11c) promoter. Cre-mediated recombination is detected in more than 95% of conventional CD11chigh dendritic cells both from lymphoid organs and from non-lymphoid tissues such as lung and epidermis, and in 50-80% of plasmacytoid dendritic cells. The dendritic cell compartment of transgenic mice is normal. Relatively low amounts of recombination are detected in lymphocytes (<10%), NK cells (12%), and myeloid cells (<1%). No increase of recombination frequency was observed in CD11clow- activated T cells. These Cd11c-cre transgenic mice (as well as CD11c-Cre-GFP transgenic mice (see Stock No.007567)) are an effective tool for generating tissue-specific targeted mutants for studying dendritic cell homeostasis and function.（来自Jackson网站）
品系名称：FVB/N-Tg(ACTB-cre)2Mrt/J
基本信息
简称：A-cre;Act-Cre;
编号：003376 (Jackson)
科技资源标识：
分类：小鼠,基因工程小鼠,转基因
繁殖方案：Homozygote x Homozygote（♀ × ♂）
代次：？ F6（2015-04-27）
来源：
→ A transgenic insert designed by Drs. Mark Lewandoski and Gail R. Martin (University of California, San Francisco) containing Cre recombinase under the control of the human beta-actin promoter was injected into fertilized FVB/N mouse eggs. Founder line 2 was subsequently established. The mice were maintained on the FVB/N background.（来自Jackson网站）
→ 2013年1月自南京大学引进种鼠；
→ 同胞兄妹交配6代；
引种和保存：
2013年1月19日引入本单位
功能及用途：
This mouse can be used to support research in many areas including:
Research Tools
Cre-lox System
Cre Recombinase Expression
Cre Recombinase Expression: Germline/Embryonic Expression
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System
Cre related
Research Tools
Cre-lox System
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System （来自Jackson网站）
生物学特征描述：
This transgenic strain expresses Cre recombinase under the control of the human beta actin gene promoter. Cre recombinase activity is detected in all cells of the embryo by the blastocyst stage of development. It is useful as a "deletor" mouse for virtually any genomic sequence flanked by loxP sites. Homozygotes are viable and fertile.（来自Jackson网站）
品系名称：B6.C-Tg(CMV-cre)1Cgn/J
基本信息
简称：CMV-cre
编号：006054 (Jackson)
科技资源标识：
分类：小鼠,基因工程小鼠,转基因
繁殖方案：纯合子 x 纯合子（♀ × ♂）
代次：N10F7 F3 F3（2014-11-03）
来源：
→ The cre gene used in this mutant mouse was modified by adding a nuclear localization signal and the human growth hormone gene providing splicing and polyadenylation signals. A construct containing cre coding sequence under the control of a human cytomegalovirus minimal promoter was introduced to BALB/cJ derived BALB/c-I embryonic stem (ES) cells. The resulting mice were backcrossed to the BALB/c background for 8 generations and then backcrossed to the C57BL/6J background for 10 generations.（来自Jackson网站）
→ 2012年9月种鼠从南京大学引进种鼠；
→ 同胞兄妹交配3代；
引种和保存：
2012年9月27日引入本单位
功能及用途：
This mouse can be used to support research in many areas including:
Research Tools
Cre-lox System
Cre Recombinase Expression
Cre Recombinase Expression: Germline/Embryonic Expression
Developmental Biology Research
Cre-lox System
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System
Tissue/Cell Markers
Tissue/Cell Markers: Cre-lox System
cre related
Research Tools
Cre-lox System
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System （来自Jackson网站）
生物学特征描述：
In this transgenic strain, deletion of loxP-flanked genes occurs in all tissues, including germ cells. The cre gene in this strain is under the transcriptional control of a human cytomegalovirus minimal promoter and is likely to be expressed before implantation during early embryogenesis. It also appears that the cre gene is X-linked since transgene transmission through males is restricted to female offspring.（来自Jackson网站）
品系名称：B6.FVB-Tg(EIIa-cre)C5379Lmgd/J
基本信息
简称：E2a-Cre;
编号：003724 (Jackson)
科技资源标识：
分类：小鼠,基因工程小鼠,转基因
繁殖方案：Homozygote x Homozygote（♀ × ♂）
代次：？ F5（2015-03-25）
来源：
→ The EIIa-cre plasmid was constructed by replacing the human cytomegalovirus promoter in pBS185 with the adenovirus EIIa promoter from pEII-lacZ. The donating investigator indicates the donor strain was FVB/N and the resulting transgenic mice were bred to C57BL/6NCr (see SNP note below) for 11 generations before arriving at The Jackson Laboratory Repository.（来自Jackson网站）
→ 种鼠来自南京大学；
→ 同胞兄妹交配5代
引种和保存：
2012年10月引入本单位
功能及用途：
This mouse can be used to support research in many areas including:
Research Tools
Cre-lox System
Cre Recombinase Expression
Cre Recombinase Expression: Germline/Embryonic Expression
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System
Cre related
Research Tools
Cre-lox System
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System（来自Jackson网站）
生物学特征描述：
This line carries a cre transgene under the control of the adenovirus EIIa promoter that targets expression of Cre recombinase to the early mouse embryo. Cre expression is thought to occur prior to implantation in the uterine wall. A mosaic pattern of expression is commonly observed. Cre-mediated recombination occurs in a wide range of tissues, including the germ cells that transmit the genetic alteration to progeny. These mice may be useful for breeding to other mice carrying loxP-flanked DNA sequences of interest. This would readily generate progeny in which Cre-mediated excision of the targeted sequences has occurred.（来自Jackson网站）
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