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品系名称：C3H/HeJNifdc
基本信息
简称：C3H；C3
编号：NR00209
科技资源标识：CSTR:15497.09.NR00209
分类：小鼠,近交系
繁殖方案：兄妹交配
代次：？ F19（2004年在我单位进行剖腹产进化）
来源：
→ 1920年Strong将一只Bagg albino雌鼠和一只DBA雄鼠进行杂交得到该品系，1930年Andervont引入了该品系的4只雌性和2只雄性鼠，随后Heston引入了第35代，1951年NIH从Heston引入第57代，1974年Charles River从NIH引入并于1975年进行了剖腹产，2001年维通利华从Charles River引入该品系1974年Charles River从NIH引入并于1975年进行剖腹产
→ 2001年维通利华从Charles River引入该品系。
引种和保存：
2001年从维通利华引入本单位
功能及用途：
主要用于肿瘤学、生理学、免疫学等研究。
生物学特征描述：
棕灰色（野生型），对致肝癌因子敏感，10月龄乳腺癌发病率97%,14月龄雄性小鼠肝癌发病率85%，对狂犬病毒敏感，对炭疽杆菌有抗力，补体活性高，较易诱发免疫耐受，红细胞及白细胞数较少。
血液生理参数
血液生理参数（4周龄）
| 参数 | 雄性 | 雌性 |
| 红细胞计数 | 8.68±0.61×10^6/μL | 9.23±0.62×10^6/μL |
| 红细胞体积 | 62.94±1.10fL | 61.54±1.13fL |
| 红细胞分布宽度 | 13.67±0.24%CV | 13.66±0.31%CV |
| 血红蛋白 | 137.00±9.60g/L | 145.00±10.37g/L |
| 压积 | 54.64±3.79% | 56.78±3.77% |
| 血红蛋白含量 | 15.79±0.30pg | 15.70±0.26pg |
| 血红蛋白浓度 | 250.60±4.17g/L | 255.40±5.19g/L |
| 白细胞计数 | 4.30±0.79×10^3/μL | 5.76±1.48×10^3/μL |
| 淋巴细胞 | 96.36±1.73% | 97.92±2.29% |
| 血小板计数 | 650.50±72.78×10^3/μL | 661.30±71.16×10^3/μL |
| 血小板平均容积 | 2.31±0.20fL | 2.41±0.25fL |
| 血小板分布宽度 | 21.60±0.69% | 20.78±1.15% |
血液生理参数（8周龄）
| 参数 | 雄性 | 雌性 |
| 红细胞计数 | 8.58±1.57×10^6/μL | 9.07±0.64×10^6/μL |
| 红细胞体积 | 60.66±2.86fL | 58.95±1.78fL |
| 红细胞分布宽度 | 13.77±1.44%CV | 13.25±0.21%CV |
| 血红蛋白 | 132.63±20.29g/L | 141.20±11.26g/L |
| 压积 | 51.71±8.29% | 53.45±3.99% |
| 血红蛋白含量 | 15.59±0.84pg | 15.56±0.31pg |
| 血红蛋白浓度 | 256.90±7.02g/L | 264.16±8.51g/L |
| 白细胞计数 | 7.74±1.40×10^3/μL | 5.69±0.92×10^3/μL |
| 淋巴细胞 | 99.44±0.70% | 99.39±0.82% |
| 血小板计数 | 684.13±124.86×10^3/μL | 579.24±100.98×10^3/μL |
| 血小板平均容积 | 2.38±0.48fL | 2.60±0.47fL |
| 血小板分布宽度 | 20.46±0.99% | 20.86±0.88% |
血液生化参数
血液生化参数（4周龄）
| 参数 | 雄性 | 雌性 |
| Ca | 2.58±0.05mmol/L | 2.66±0.12mmol/L |
| P | 3.49±0.38mmol/L | 3.58±0.31mmol/L |
| 门冬氨酸氨基转氨酶 | 100.24±15.71U/L | 154.58±114.74U/L |
| 丙氨酸氨基转氨酶 | 21.48±5.02U/L | 38.92±26.29U/L |
| 碱性磷酸酶 | 238.75±11.76U/L | 287.84±12.44U/L |
| 肌苷 | 48.40±1.00mmol/L | 57.23±13.22mmol/L |
| 尿素氮 | 8.66±0.81mmol/L | 10.41±1.31mmol/L |
| 总胆固醇 | 4.15±0.14mmol/L | 3.31±0.17mmol/L |
| 血清总蛋白 | 55.88±1.36g/L | 57.21±3.82g/L |
| 白蛋白 | 35.60±1.80g/L | 36.63±3.19g/L |
| 甘油三脂 | 1.73±0.43mmol/L | 1.56±0.25mmol/L |
| 血糖 | 4.48±0.41mmol/L | 2.64±0.61mmol/L |
血液生化参数（8周龄）
| 参数 | 雄性 | 雌性 |
| Ca | 2.28±0.44mmol/L | 2.39±0.08mmol/L |
| P | 2.86±0.69mmol/L | 3.17±0.21mmol/L |
| 门冬氨酸氨基转氨酶 | 220.79±184.13U/L | 243.76±124.25U/L |
| 丙氨酸氨基转氨酶 | 44.43±33.09U/L | 41.60±27.75U/L |
| 碱性磷酸酶 | 171.72±47.79U/L | 237.04±19.24U/L |
| 肌苷 | 59.10±18.80mmol/L | 91.43±36.93mmol/L |
| 尿素氮 | 10.53±5.11mmol/L | 9.27±1.25mmol/L |
| 总胆固醇 | 3.56±0.78mmol/L | 3.23±0.24mmol/L |
| 血清总蛋白 | 61.09±12.45g/L | 63.00±2.57g/L |
| 白蛋白 | 39.63±7.95g/L | 42.35±1.56g/L |
| 甘油三脂 | 2.97±1.01mmol/L | 2.53±0.77mmol/L |
| 血糖 | 3.73±0.98mmol/L | 3.32±0.67mmol/L |
品系名称：B6.Cg-Tg(Ins2-cre)25Mgn/J
基本信息
简称：Rip-cre; InS-cre;
编号：003573 (Jackson)
科技资源标识：
分类：小鼠,基因工程小鼠,转基因
繁殖方案：纯合子 x 纯合子（♀ × ♂）
代次：？ N6 F2N3 （2015-04-23）
来源：
→ A transgenic construct containing a 668 bp rat insulin II promoter, nuclear localization sequence-modified Cre recombinase and a 2.1 kbp fragment from the human growth hormone gene was injected into B6D2(F2) pronuclei. The allele was subsequently moved to a C57BL/6J background.（来自Jackson网站）
→ 2012年5月从南京大学引进回交6代种鼠；
→ 同胞兄妹交配2代；
→ 与本单位B6回交3代；
引种和保存：
2012年5月31日引入本单位
功能及用途：
This mouse can be used to support research in many areas including:
Diabetes and Obesity Research
Type 1 Diabetes (IDDM)
Research Tools
Cardiovascular Research
Cre-lox System
Cre-lox System
Cre Recombinase Expression
Diabetes and Obesity Research
loxP
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System
Tissue/Cell Markers: Cre-lox System
Tissue/Cell Markers: pancreatic beta cells
Cre related
Research Tools
Cre-lox System
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System （来自Jackson网站）
生物学特征描述：
This strain carries the "RIP-Cre" transgene construct (containing a 668 bp fragment of the rat insulin II promoter, Cre recombinase with a nuclear localization sequence, and a 2.1 kb fragment from the human growth hormone gene). Hemizygous mice carrying this transgene are phenotypically normal and overexpresss cre specifically in pancreatic beta cells. This transgene strain is used in combination with mice carrying floxed targeted mutations to create various pancreatic beta cell-specific gene knockouts using the "Cre-lox" system. Results from several different laboratories have shown that this transgenic strain is at least 85% efficient in achieving pancreatic beta cell-specific recombination. It should also be noted that the transgene in this line has been found to be expressed at a low level in the hypothalamus. In some cases this has resulted in a phenotype due to deletion of the floxed allele in this region of the brain. It has also been shown that these transgenic mice may spontaneously develop glucose intolerance and impaired insulin secretion developing at 6-8 weeks of age. It is recommended that users include naive "RIP-Cre" mice (i.e., those not bred to a floxed mutant) among the controls used in experiments.（来自Jackson网站）
品系名称：B6.129P2(C)-Cd19tm1(cre)Cgn/J
基本信息
简称：Cd19cre；
编号：006785 (Jackson)
科技资源标识：
分类：小鼠,基因工程小鼠
繁殖方案：Homozygote x Homozygote（♀ × ♂）
代次：N11 F5 N1F4 F6（2015-04-20）
来源：
→ A targeting vector containing Cre recombinase, the rabbit beta-globin intron /poly A signal sequence, and an FRT-flanked neomycin resistance gene, was used to disrupt exon 2 of the Cd19 gene and to express cre under the regulation of the endogenous promoter. Herpes simplex virus thymidine kinase gene was placed 3' of the Cd19 sequence to allow for the selection against random integration. The construct was transfected into 129P2/OlaHsd-derived E14-1 embryonic stem cells. Correctly targeted ES cells were injected into 129/Sv blastocysts. The resulting chimeric animals were backcrossed to BALB/c IgHb congenics for a number of generations and then backcrossed to C57BL/6 for 10 generations.（来自Jackson网站）
→ 2012年6月从南京大学引进；
→ 同胞兄妹交配繁殖6代；
引种和保存：
2012年6月引入本单位
功能及用途：
This mouse can be used to support research in many areas including:
Developmental Biology Research
Internal/Organ Defects
hematopoietic defects
Lymphoid Tissue Defects
hematopoietic defects
Hematological Research
Hematopoietic Defects
Immunology, Inflammation and Autoimmunity Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
genes regulating susceptibility to infectious disease and endotoxin
Immunodeficiency
B cell defects
B cell deficiency
Lymphoid Tissue Defects
hematopoietic development
Research Tools
Cardiovascular Research
Cre-lox System
Cre-lox System
Cre Recombinase Expression
Developmental Biology Research
Cre-lox System
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System
Tissue/Cell Markers: Cre-lox System
Immunology, Inflammation and Autoimmunity Research
B cell deficiency
cre related
Research Tools
Cre-lox System
Cd19tm1(cre)Cgn related
Hematological Research
Hematopoietic Defects
Immunology, Inflammation and Autoimmunity Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Immunodeficiency
B cell defects
Research Tools
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System（来自Jackson网站）
生物学特征描述：
Homozygous mutant mice are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities. Homozygotes have a deficiency in the B-1 subset of B-lymphocytes along with a concomitant reduction in serum IgM. Their ability to respond to T-cell-dependent antigens is severely impaired, and they fail to form splenic germinal centers.
In addition to disrupting the targeted gene, the targeting construct also introduced acre cassette into exon 2 of the targeted gene, effectively placingcre expression under the control of the endogenous promoter. The Cd19 promoter specifically directs cre expression at the earliest stages and throughout B-lymphocyte development and differentiation. Although homozygous mutant mice are Cd19-deficient, heterozygous mice are phenotypically normal, and can be used for specific deletion of loxP-flanked (floxed) targets in B-lymphocytes.
In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available.（来自Jackson网站）
品系名称：B6.Cg-Tg(Lck-cre)548Jxm /J
基本信息
简称：Lck-cre;
编号：003802 (Jackson)
科技资源标识：
分类：小鼠,基因工程小鼠,转基因
繁殖方案：纯合子 x 纯合子（♀ × ♂）
代次：？ N4 6N1F6 N7 N3 （2015-04-23）
来源：
→ A transgenic construct containing a Cre recombinase gene under the control of the Lck promoter was used to create this mutation. The construct was injected either into B6D2F1 or B6CBAF2 zygotes to obtain founder animals. （来自Jackson网站）
→ 2012年5月从南京大学引进种鼠；
→ 与本单位B6回交3代；
引种和保存：
2012年5月31日引入本单位
功能及用途：
This mouse can be used to support research in many areas including:
Research Tools
Cre-lox System
Cre Recombinase Expression
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System
Cre related
Research Tools
Cre-lox System
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System （来自Jackson网站）
生物学特征描述：
This transgenic strain expresses Cre under the control of the Lck (lymphocyte protein tyrosine kinase) promoter, enabling thymocyte-specific excision of loxP-flanked sequences of interest. Homozygous mice are viable and have no major defects.
When crossed with floxed Galnt13 mice (see Stock No. 006896), excision occurs at high efficiency in thymocytes. Splenic CD4 T cells show excision at somewhat lower rates (66-83%).
The Lck gene is primarily expressed by T lymphocytes where it phosphorylates tyrosine residues of proteins involved with intracellular signaling pathways. Associating with CD4 and CD8, LCK is part of a cascade of responses to antigen that control the proliferation and activation of T cells. It plays a key role in the selection and maturation of developing T-cells in the thymus and in the activity of mature T-cells.（来自Jackson网站）
品系名称：
FVB/NJNjuNifdc
基本信息
简称：FVB;
编号：001800 (Jackson)
科技资源标识：
分类：小鼠,近交系
繁殖方案：兄妹交配（♀ × ♂）
代次：？ F2 （2015-04-20）
来源：
→ In 1966, outbred Swiss mice at the National Institutes of Health were selectively bred for either resistance or sensitivity to histamine challenge post pertussis vaccination. At the eighth generation of inbreeding (in the early 1970s), the sensitive line, HSFS/N, was found to carry the Fv1b allele which confers sensitivity to the Friend leukemia virus B strain. The FVB/N strain resulted from inbreeding this line for the Fv1b allele. In 1988 FVB/N mice were imported from NIH to Dr. Taketo at The Jackson Laboratory and in 1991 these were re-derived at F50 into the foundation stocks facility at The Jackson Laboratory. In December 2002 this strain reached F87.（来自Jackson网站）
→ 2014年11月从南京大学引进种鼠；（FVB/NJju）
→ 同胞兄妹交配2代，；
引种和保存：
2014年11月26日引入本单位
功能及用途：
This mouse can be used to support research in many areas including:
Research Tools
General Purpose
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Production of Transgenic Mice, large pronuclei
Infectious Disease
Salmonella
Sensorineural Research
Retinal Degeneration
Homozygous for Pde6brd1
Hc0 related
Immunology, Inflammation and Autoimmunity Research
Immunodeficiency
specific complement deficiency
Research Tools
Immunology, Inflammation and Autoimmunity Research
specific complement deficiency, C5 complement
Pde6brd1 related
Sensorineural Research
Retinal Degeneration （来自Jackson网站）
生物学特征描述：
FVB/NJ was inbred for the Fv1b allele which confers sensitivity to the Friend leukemia virus B strain. Due to the prominent pronuclei in their fertilized eggs and the large litter size, FVB/NJ mice are commonly used for transgenic injection. Compared to many other inbred strains, FVB/NJ is highly susceptible to asthma-like airway responsiveness with significant generation of antigen-specific IgE. Despite having the H2q MHC haplotype, FVB/NJ are resistant to collagen-induced arthritis. This resistance stems from coding polymorphisms in Tcra-V11.1 and a genomic deletion of some Tcrb-V genes that includes Tcrb-V8.2. FVB/NJ have higher than average activity, anxiety, and basal body temperature, low stress-induced hyperthermia, and are homozygous for the Pde6brd1 allele, which results in early onset retinal degeneration. Although FVB/N typically do not develop spontaneous tumors, they are highly susceptible to chemically induced squamous cell carcinomas with a high rate of malignant conversion from papilloma to carcinoma.（来自Jackson网站）
品系名称：
DBA/2Nifdc
基本信息
简称：DBA/2;
编号：
科技资源标识：
分类：小鼠,近交系
繁殖方案：同胞兄妹
代次：？ F81 （2015-11-26）
来源：
→ 1990年从澳大利亚引入
引种和保存：
引入本单位时间不详
功能及用途：
主要用于肿瘤学、遗传学、免疫学的研究。
生物学特征描述：
免疫：在普通饲养条件下三月龄鼠血清免疫球蛋白量为1000ug/ml左右，仅相当C57BL/6，C3H/He和BALB/c的1/2。其中，IgM值较高，而IgG为低值。在IgG各亚类中，IgG1高低，IgG2最低。肿瘤：对DBA/1 的大部分移植瘤有抗性。雌鼠白血病发病率为34％，雄鼠为18％，经产母鼠乳腺癌发生率为50- 60％，雌雄鼠中均有淋巴瘤生长。微生物和寄生虫：对疟原虫、利什曼原虫有抗力。对猫后睾吸虫、曼氏血吸虫较敏感。对白色念球菌有抗力，由于具有Hc0等位基因， 对新型隐球菌有抗力。生理：红细胞多。血压较低。维生素Ｋ缺乏，氯仿和氧化乙烯引起的死亡率高。肾上腺脂质贮存少，心脏有钙盐沉着。具低嗜酒性及吗啡嗜好。对百日咳组织胺易感因子敏感。病理：听源性癫痫发作率在35日龄时为100％，55日龄时为5％，约一半动物肝可出现由巨噬细胞构成的蜡样质的肉芽肿。
血液生理参数
血液生理参数（4周龄）
| 参数 | 雄性 | 雌性 |
| 红细胞计数 | 7.68±0.98×10^6/μL | 8.38±0.83×10^6/μL |
| 红细胞体积 | 53.64±3.03fL | 52.96±2.69fL |
| 红细胞分布宽度 | 14.57±0.99%CV | 14.42±1.23%CV |
| 血红蛋白 | 123.90±15.92g/L | 138.17±9.75g/L |
| 压积 | 41.07±4.59% | 44.25±2.77% |
| 血红蛋白含量 | 16.15±0.89pg | 16.53±0.81pg |
| 血红蛋白浓度 | 301.30±6.45g/L | 312.17±3.76g/L |
| 白细胞计数 | 9.83±1.91×10^3/μL | 7.81±0.72×10^3/μL |
| 淋巴细胞 | 98.14±1.38% | 99.10±1.11% |
| 血小板计数 | 686.70±112.51×10^3/μL | 599.67±121.76×10^3/μL |
| 血小板平均容积 | 2.23±0.37fL | 2.14±0.53fL |
| 血小板分布宽度 | 19.05±0.92% | 19.41±0.81% |
血液生理参数（8周龄）
| 参数 | 雄性 | 雌性 |
| 红细胞计数 | 8.83±0.96×10^6/μL | 10.46±0.71×10^6/μL |
| 红细胞体积 | 50.32±1.50fL | 48.58±0.54fL |
| 红细胞分布宽度 | 13.54±0.59%CV | 12.98±0.13%CV |
| 血红蛋白 | 135.92±15.25g/L | 159.00±11.16g/L |
| 压积 | 44.35±4.21% | 50.80±3.50% |
| 血红蛋白含量 | 15.39±0.50pg | 15.22±0.35pg |
| 血红蛋白浓度 | 306.08±7.18g/L | 312.80±5.76g/L |
| 白细胞计数 | 7.08±1.81×10^3/μL | 7.22±2.45×10^3/μL |
| 淋巴细胞 | 99.08±0.73% | 99.40±0.34% |
| 血小板计数 | 344.5±188.97×10^3/μL | 677.40±69.89×10^3/μL |
| 血小板平均容积 | 3.63±1.74fL | 2.00±0.19fL |
| 血小板分布宽度 | 19.18±1.00% | 18.58±0.83% |
血液生化参数
血液生化参数（4周龄）
| 参数 | 雄性 | 雌性 |
| Ca | 2.10±0.28mmol/L | 2.28±0.06mmol/L |
| P | 3.25±0.46mmol/L | 3.30±0.36mmol/L |
| 门冬氨酸氨基转氨酶 | 159.60±81.79U/L | 179.50±68.67U/L |
| 丙氨酸氨基转氨酶 | 57.90±67.94U/L | 62.00±41.58U/L |
| 碱性磷酸酶 | 109.50±32.60U/L | 123.25±24.62U/L |
| 肌苷 | 49.05±8.46mmol/L | 89.80±20.00mmol/L |
| 尿素氮 | 11.39±2.73mmol/L | 8.74±1.28mmol/L |
| 总胆固醇 | 2.66±0.41mmol/L | 2.28±0.45mmol/L |
| 血清总蛋白 | 51.78±8.30g/L | 55.70±3.19g/L |
| 白蛋白 | 35.49±5.68g/L | 39.92±2.47g/L |
| 甘油三脂 | 2.34±1.06mmol/L | 3.91±0.94mmol/L |
| 血糖 | 3.13±0.98mmol/L | 2.31±0.56mmol/L |
血液生化参数（8周龄）
| 参数 | 雄性 | 雌性 |
| Ca | 1.97±0.09mmol/L | 2.25±0.08mmol/L |
| P | 3.63±0.94mmol/L | 3.36±0.57mmol/L |
| 门冬氨酸氨基转氨酶 | 3782.25±2153.88U/L | 242.00±78.11U/L |
| 丙氨酸氨基转氨酶 | 3818.62±2394.18U/L | 35.00±7.27U/L |
| 碱性磷酸酶 | 91.12±32.66U/L | 85.00±19.78U/L |
| 肌苷 | 53.25±4.88mmol/L | 55.25±5.15mmol/L |
| 尿素氮 | 19.56±4.66mmol/L | 12.80±4.74mmol/L |
| 总胆固醇 | 3.14±0.59mmol/L | 2.42±0.11mmol/L |
| 血清总蛋白 | 53.18±3.25g/L | 62.05±3.51g/L |
| 白蛋白 | 34.12±2.35g/L | 42.50±1.97g/L |
| 甘油三脂 | 2.94±1.06mmol/L | 2.34±0.84mmol/L |
| 血糖 | 3.15±0.84mmol/L | 3.58±1.20mmol/L |
品系名称：
NCPC/2Nifdc
基本信息
简称：NCPC/2
编号：
科技资源标识：
分类：小鼠,近交系,自发突变
繁殖方案：同胞兄妹（♀ × ♂）
代次：F？ F6 F63 F26（2015-11-25）
来源：
→ 1988年由河北医学院，河北制药厂等昆明种为原种，经F？ F6传代而成。
引种和保存：
2002年11月25日由河北华药动物中心引入本单位
功能及用途：
肿瘤学，生理学，免疫学，遗传研究中心中常用品系。
生物学特征描述：
被毛白色，对S180移植肿瘤易感性较C57BL/6或NIH小鼠易感，并具备有生长速度快的特点。易被白色念珠菌和微球菌感染。繁殖能力强。
血液生理参数
血液生理参数（4周龄）
| 参数 | 雄性 | 雌性 |
| 红细胞计数 | 8.9±0.53×10^6/μL | 8.9±0.70×10^6/μL |
| 红细胞体积 | 55.7±2.00fL | 55.8±1.17fL |
| 红细胞分布宽度 | 16.3±1.30%CV | 16.6±0.56%CV |
| 血红蛋白 | 143.2±9.92g/L | 137.4±9.21g/L |
| 压积 | 49.6±2.09% | 49.4±3.56% |
| 血红蛋白含量 | 16.1±0.65pg | 15.5±0.30pg |
| 血红蛋白浓度 | 288.9±18.51g/L | 278.4±4.30g/L |
| 白细胞计数 | 5.4±1.16×10^3/μL | 4.8±0.98×10^3/μL |
| 淋巴细胞 | 81.4±6.88% | 83.2±3.51% |
| 血小板计数 | 590.0±243.46×10^3/μL | 587.4±136.42×10^3/μL |
| 血小板平均容积 | 5.6±1.87fL | 5.1±0.87fL |
| 血小板分布宽度 | 18.4±1.06% | 18.7±1.12% |
血液生理参数（8周龄）
| 参数 | 雄性 | 雌性 |
| 红细胞计数 | 11.8±0.67×10^6/μL | 11.0±0.57×10^6/μL |
| 红细胞体积 | 51.8±1.39fL | 52.8±1.05fL |
| 红细胞分布宽度 | 14.3±0.48%CV | 14.4±0.49%CV |
| 血红蛋白 | 159.0±7.73g/L | 154.9±5.05g/L |
| 压积 | 61.6±3.66% | 58.6±3.26% |
| 血红蛋白含量 | 13.4±0.53pg | 14.0±0.47pg |
| 血红蛋白浓度 | 158.7±13.02g/L | 264.8±9.40g/L |
| 白细胞计数 | 3.7±1.20×10^3/μL | 4.0±1.07×10^3/μL |
| 淋巴细胞 | 78.2±8.12% | 86.4±6.50% |
| 血小板计数 | 558.7±208.88×10^3/μL | 631.5±153.86×10^3/μL |
| 血小板平均容积 | 631.5±153.86fL | 3.8±0.67fL |
| 血小板分布宽度 | 16.5±1.12% | 17.2±0.81% |
血液生化参数
血液生化参数（4周龄）
| 参数 | 雄性 | 雌性 |
| Ca | 2.929±0.149mmol/L | 2.784±0.187mmol/L |
| P | 3.299±0.352mmol/L | 3.144±0.22mmol/L |
| 门冬氨酸氨基转氨酶 | 125.8±26.5U/L | 158.6±124.4U/L |
| 丙氨酸氨基转氨酶 | 28.6±11.7U/L | 26.3±7.9U/L |
| 碱性磷酸酶 | 365.4±46.8U/L | 361.2±38.1U/L |
| 尿素氮 | 8.166±0.953mmol/L | 7.564±0.62mmol/L |
| 总胆固醇 | 3.9309±0.3428mmol/L | 2.5594±0.1575mmol/L |
| 血清总蛋白 | 60.779±3.329g/L | 57.324±3.08g/L |
| 白蛋白 | 35.942±1.291g/L | 35.586±1.731g/L |
| 甘油三脂 | 2.1286±0.4014mmol/L | 1.6153±0.4334mmol/L |
| 血糖 | 4.933±0.819mmol/L | 4.231±1.072mmol/L |
血液生化参数（8周龄）
| 参数 | 雄性 | 雌性 |
| Ca | 2.754±0.069mmol/L | 2.738±0.087mmol/L |
| P | 3.048±0.364mmol/L | 2.967±0.258mmol/L |
| 门冬氨酸氨基转氨酶 | 116.4±23.8U/L | 113.1±15.5U/L |
| 丙氨酸氨基转氨酶 | 51±41.6U/L | 34.2±32.5U/L |
| 碱性磷酸酶 | 183.1±16.5U/L | 251.1±26.9U/L |
| 尿素氮 | 8.601±1.308mmol/L | 11.251±5.219mmol/L |
| 总胆固醇 | 3.7281±0.2615mmol/L | 2.6006±0.376mmol/L |
| 血清总蛋白 | 60.139±2.879g/L | 58.729±3.019g/L |
| 白蛋白 | 34.837±1.066g/L | 36.178±1.242g/L |
| 甘油三脂 | 1.6461±0.3907mmol/L | 1.2462±0.2756mmol/L |
| 血糖 | 6.28±0.926mmol/L | 5.322±0.499mmol/L |
品系名称：
T739/Nifdc
基本信息
简称：T739
编号：
科技资源标识：
分类：小鼠,近交系
繁殖方案：兄妹交配（♀ × ♂）
代次：F42 F？ F21（2015-12-10）
来源：
→ 天津市医药科学研究所，1973年用615雄性与KM雌性小鼠杂交44代育成。
→ 1986年从天津引进F42代种鼠；
→ 本单位2005年从肿瘤医院引进种子，同胞兄妹交配21代。
引种和保存：
2005年引入本单位
功能及用途：
天津市医药科学研究所动物实验室在T739小鼠上建立了两个可移植性瘤株，即可移植性肺腺癌LA795和可移植性胸腹水型淋巴细胞白血病模型L845。因此T739小鼠模型是进行肿瘤实验研究和抗癌药物筛选的有用工具，已被广泛应用于实验肿瘤学、抗肿瘤药物的筛选和遗传学等方面的研究。
生物学特征描述：
血液生理参数
血液生理参数（8周龄）
| 参数 | 雄性 | 雌性 |
| 红细胞计数 | 8.86±0.82×10^6/μL | 9.24±0.71×10^6/μL |
| 红细胞体积 | 49.85±0.33fL | 49.13±0.40fL |
| 红细胞分布宽度 | 14.39±0.49%CV | 14.44±0.47%CV |
| 血红蛋白 | 136.67±12.40g/L | 143.93±10.50g/L |
| 压积 | 44.19±4.10% | 45.39±3.50% |
| 血红蛋白含量 | 15.43±0.25pg | 15.61±0.23pg |
| 血红蛋白浓度 | 309.47±5.11g/L | 317.20±4.81g/L |
| 白细胞计数 | 6.21±0.94×10^3/μL | 7.17±1.31×10^3/μL |
| 淋巴细胞 | 99.38±1.27% | 99.32±1.06% |
| 血小板计数 | 598.33±58.03×10^3/μL | 528.60±108.54×10^3/μL |
| 血小板平均容积 | 1.85±0.56fL | 1.96±0.74fL |
| 血小板分布宽度 | 18.7±0.91% | 18.89±0.59% |
血液生理参数（4周龄）
| 参数 | 雄性 | 雌性 |
| 红细胞计数 | 10.30±1.61×10^6/μL | 10.16±0.50×10^6/μL |
| 红细胞体积 | 46.67±0.34fL | 48.08±0.59fL |
| 红细胞分布宽度 | 12.68±0.33%CV | 13.05±0.37%CV |
| 血红蛋白 | 152.91±24.10g/L | 154.94±7.84g/L |
| 压积 | 48.06±7.39% | 48.80±2.44% |
| 血红蛋白含量 | 14.85±0.22pg | 15.26±0.19pg |
| 血红蛋白浓度 | 318.00±4.23g/L | 318.69±4.94g/L |
| 白细胞计数 | 5.98±2.14×10^3/μL | 7.54±1.97×10^3/μL |
| 淋巴细胞 | 90.89±22.77% | 99.05±1.61% |
| 血小板计数 | 726.50±122.46×10^3/μL | 645.94±63.16×10^3/μL |
| 血小板平均容积 | 1.56±0.19fL | 1.75±0.19fL |
| 血小板分布宽度 | 17.93±0.73% | 18.68±0.78% |
血液生化参数
血液生化参数（4周龄）
| 参数 | 雄性 | 雌性 |
| Ca | 1.86±0.16mmol/L | 1.81±0.13mmol/L |
| P | 2.31±0.29mmol/L | 2.44±0.38mmol/L |
| 门冬氨酸氨基转氨酶 | 156.82±86.90U/L | 154.69±65.60U/L |
| 丙氨酸氨基转氨酶 | 39.41±40.41U/L | 27.75±12.70U/L |
| 碱性磷酸酶 | 168.41±36.56U/L | 173.81±15.55U/L |
| 肌苷 | 50.36±5.09mmol/L | 49.59±4.17mmol/L |
| 尿素氮 | 8.56±0.99mmol/L | 7.55±1.10mmol/L |
| 总胆固醇 | 2.51±0.33mmol/L | 1.73±0.24mmol/L |
| 血清总蛋白 | 56.59±4.94g/L | 54.38±2.87g/L |
| 白蛋白 | 39.11±3.43g/L | 39.13±2.21g/L |
| 甘油三脂 | 1.42±0.28mmol/L | 0.98±0.16mmol/L |
| 血糖 | 5.63±1.51mmol/L | 4.51±1.62mmol/L |
血液生化参数（8周龄）
| 参数 | 雄性 | 雌性 |
| Ca | 2.08±0.03mmol/L | 2.07±0.09mmol/L |
| P | 3.81±0.31mmol/L | 3.52±0.25mmol/L |
| 门冬氨酸氨基转氨酶 | 105.00±25.86U/L | 107.20±9.45U/L |
| 丙氨酸氨基转氨酶 | 22.00±6.48U/L | 23.60±5.42U/L |
| 碱性磷酸酶 | 314.20±17.66U/L | 365.00±29.93U/L |
| 肌苷 | 54.60±4.42mmol/L | 61.10±12.21mmol/L |
| 尿素氮 | 10.18±0.94mmol/L | 8.90±0.93mmol/L |
| 总胆固醇 | 3.39±0.26mmol/L | 2.21±0.26mmol/L |
| 血清总蛋白 | 55.88±2.04g/L | 56.28±2.19g/L |
| 白蛋白 | 38.46±1.74g/L | 40.06±1.32g/L |
| 甘油三脂 | 2.26±0.40mmol/L | 1.72±0.44mmol/L |
| 血糖 | 3.11±0.41mmol/L | 2.36±0.52mmol/L |
品系名称：B6.Cg-Lepob/J
基本信息
简称：B6 ob;
编号：000632 (Jackson)
科技资源标识：
分类：小鼠,基因工程小鼠,自发突变
繁殖方案：Heterozygote (Homozygote) x Heterozygote（♀ × ♂）
代次：？ F5 （2014-12-11）
来源：
→ The obese mutation, ob, arose spontaneously in strain V/Le at The Jackson Laboratory, Bar Harbor, Maine in 1949, and has been backcrossed to C57BL/6J for more than 45 generations.（来自Jackson网站）
→ 同胞兄妹交配繁殖5代；
引种和保存：
2008年12月10日南大引入本单位
功能及用途：
This mouse can be used to support research in many areas including:
Diabetes and Obesity Research
Hyperglycemia
transient
Type 2 Diabetes (NIDDM)
transient
Internal/Organ Research
Skeleton
Bone
Wound Healing
delayed/impaired
Lepob related
Diabetes and Obesity Research
Hyperinsulinemia
Impaired Wound Healing
Insulin Resistance
Obesity With Diabetes
Endocrine Deficiency Research
Adipose Defects
Hypothalamus/Pituitary Defects
Pancreas Defects
Immunology, Inflammation and Autoimmunity Research
Immunodeficiency Associated with Other Defects
Internal/Organ Research
Adipose Defects
Metabolism Research
Reproductive Biology Research
Fertility Defects（来自Jackson网站）
生物学特征描述：
Mice homozygous for the obese spontaneous mutation, (Lepob; commonly referred to as ob or ob/ob), are first recognizable at about four weeks of age. Homozygous mutant mice gain weight rapidly and may reach three times the normal weight of wild-type controls. In addition to obesity, mutant mice exhibit hyperphagia, a diabetes-like syndrome of hyperglycemia, glucose intolerance, elevated plasma insulin, subfertility, impaired wound healing, and an increase in hormone production from both pituitary and adrenal glands. They are also hypometabolic and hypothermic. The obesity is characterized by an increase in both adipocyte number and size. Adipose tissue transplants in Lepob homozygotes protect them from obesity, normalize insulin sensitivity, and restore fertility. Although hyperphagia contributes to the obesity, homozygotes gain excess weight and deposit excess fat even when restricted to a diet sufficient for normal weight maintenance in lean mice. Hyperinsulinemia does not develop until after the increase in body weight, and probably results from it. Homozygotes have an abnormally low threshold for stimulation of pancreatic islet insulin secretion even in very young pre-obese animals. Female homozygotes exhibit decreased uterine and ovarian weights, decreased ovarian hormone production and hypercytolipidemia in follicular granulosa and endometrial epithelial tissue layers (Garris et al., 2004).
As is the case with mice carrying the diabetes mutation (Leprdb), manifestation of the diabetic syndrome is strikingly dependent on genetic background. Hyperglycemia is only transient, (subsiding around 14 to 16 weeks) on the C57BL/6J background. On the C57BLKS background, obese homozygotes (Stock No. 000696) become severely diabetic with regression of islets and early death. Injection of recombinant leptin into obese homozygotes sharply reduces body weight, decreases food intake, increases energy expenditure, and restores fertility in male mice.
Leptin can regulate bone mass through a central, neuroendocrine signaling pathway. Similar to the effects of aging in humans, homozygotes exhibit muscle hypoplasia (quadriceps), increased marrow adipogenesis and decreased bone mass in the hindlimbs (Hamrick et al., 2004) （来自Jackson网站）
品系名称：STOCK Igf1tm2Ts/ImJ
基本信息
简称：IGF-1 midi
编号：003259 (Jackson)
科技资源标识：
分类：小鼠,基因工程小鼠,转基因
繁殖方案：纯合子 x 纯合子（♀ × ♂）
代次：？ F7N1 （2015-11-25）
来源：
→ An entire targeting vector containing a NEO cassette inserted into exon 3 sequence, a thymidine kinase gene and vector sequences was inserted 5' of the endogenous exon 3.The construct was electroporated into 129S7/SvEvBrd-Hprt derived AB1 embryonic stem (ES) cells. ES cells which were carrying this site-specific insertion of the targeting construct rather than homologous recombination were injected into blastocysts. The resulting chimeric animals were tested for germline transmission, and bred to C57BL/6 mice. The mice were then bred to CD-1 outbred mice.（来自Jackson网站）
→ 2012年引进本单位活体保种；
→ 同胞兄妹交配7代，与B6回交一代；
引种和保存：
2012年引入本单位
功能及用途：
This mouse can be used to support research in many areas including:
Cancer Research
Genes Regulating Growth and Proliferation
Growth Factors/Receptors/Cytokines
Endocrine Deficiency Research
Mammary Gland Defects （来自Jackson网站）
生物学特征描述：
Mice homozygous for the Igf1tm2Ts mutation (also referred to as the Igf1m/m midi targeted insertion) are viable and fertile, but are small in size, reaching only approximately 60 - 65% the weight of their wild type siblings. Serum levels of IGF-1 in these mutants is 30% of wild type values. They have no gross histological abnormalities. Arterial blood pressure is higher in Igf1m/m mice than in wild type controls. The Donating Investigator reports that homozygotes are subfertile but viable, with approximately 50% of homozygous animals dying before weaning.（来自Jackson网站）
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